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1996-03-04
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Document 0837
DOCN M9640837
TI Zidovudine adherence among individuals with HIV infection.
DT 9604
AU Muma RD; Ross MW; Parcel GS; Pollard RB; Department of Physician
Assistant, College of Health Professions,; Wichita State University,
Kansas 67260-0043, USA.
SO AIDS Care. 1995;7(4):439-47. Unique Identifier : AIDSLINE MED/96119351
AB The objective was to investigate the relationships among health beliefs,
attitudes, and zidovudine compliance in individuals with HIV infection.
A survey was administered to 52 individuals with HIV infection. The
survey items, which reflected concerns expressed about zidovudine, were
generated based on barriers to and benefits of zidovudine and the
perceived susceptibility to and perceived severity of HIV as described
by the health belief model (HBM). These items were expressed as
attitudes and beliefs. Items were subjected to factor analysis, and
survey results were correlated with laboratory data to predict adherence
to their prescribed medication-taking regimen. Data indicated that 42.3%
of the subjects were compliant with zidovudine. Factor analysis
identified four dimensions: problems taking and scepticism about
zidovudine; degree of concern about HIV; perceived severity of HIV; and
physical barriers to taking zidovudine. Logistic regression analysis
(forward conditional entry) identified those who were having problems
taking zidovudine and who were sceptical about its effectiveness, and
ethnicity as significant independent predictors of compliance, correctly
classifying 75% of cases (p < 0.01). The fact that subjects who have
problems taking zidovudine or are sceptical about the value of
zidovudine are less compliant, and that this dimension is a significant
predictor of compliance, suggests that non-compliance is related to
attitudes and beliefs about zidovudine. This is consistent with the HBM,
which holds that the balance between barriers and benefits of a
health-related behaviour are significant determinants of outcome.
DE Adult Antiviral Agents/*THERAPEUTIC USE Attitude to Health Blacks
Cross-Sectional Studies Culture Factor Analysis, Statistical Female
Human HIV Infections/*DRUG THERAPY Logistic Models Male Middle Age
Models, Psychological *Patient Compliance Reverse Transcriptase
Inhibitors/*THERAPEUTIC USE Texas Zidovudine/*THERAPEUTIC USE JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).